Interpreting Results from Bayesian Network Meta-Analyses (Nma): A Guide for Non-Statisticians.

نویسندگان

  • M Pacou
  • V Taieb
  • D Belhadi
  • L Mesana
  • A Gauthier
چکیده

• ORA vs. B>1 indicates a higher response rate in favour of treatment A. • The DIC (Deviance Information Criterion) is commonly used to select fixed vs. random effects model • DIC represents a trade-off between model adequacy and complexity (i.e. complex models, for example a random effect vs a fixed effect model, are penalised) • The model associated with the lowest DIC is selected, considering a 3 to 5-point difference in DIC to be meaningful for model selection. • Fig. 5: Rankogram • Fig. 4: Forest plot – Graphical representation of the ORs and CrIs (graphical illustration of the same data as represented in Table 1)

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Approaches to interpreting and choosing the best treatments in network meta-analyses

When randomized trials have addressed multiple interventions for the same health problem, network meta-analyses (NMAs) permit researchers to statistically pool data from individual studies including evidence from both direct and indirect comparisons. Grasping the significance of the results of NMAs may be very challenging. Authors may present the findings from such analyses in several numerical...

متن کامل

An overview of conducting systematic reviews with network meta-analysis

Introduction Systematic reviews with network meta-analysis (NMA) are published with increasing frequency in the health care literature. Prior to 2008, very few systematic reviews contained a NMA [1]; however, there has been a marked increase, to mid-2012 Lee recorded 201 published networks [2]. The statistical method has been available since 2002 [3,4] and owes its origins to much earlier work ...

متن کامل

The impact of incorporating Bayesian network meta-analysis in cost-effectiveness analysis - a case study of pharmacotherapies for moderate to severe COPD

OBJECTIVE To evaluate the impact of using network meta-analysis (NMA) versus pair wise meta-analyses (PMA) for evidence synthesis on key outputs of cost-effectiveness analysis (CEA). METHODS We conducted Bayesian NMA of randomized clinical trials providing head-to-head and placebo comparisons of the effect of pharmacotherapies on the exacerbation rate in chronic obstructive pulmonary disease ...

متن کامل

Proposed Checklist for Non-Statisticians To Assess the Quality of A Network Meta-Analysis in the Context of A Nice Submission.

• An ad-hoc search of the literature was conducted to identify existing checklists. Items from these checklists were extracted and critically reviewed. • Recommendations from NICE [1,2] as well as existing NICE submissions and corresponding comments from the evidence review groups (ERG) were used to develop the checklist, which was then tested by statisticians to assess the clarity and the accu...

متن کامل

Network meta-analysis: introduction and an example that compares devices for PFO closure.

Over the last 20 years, the number of published meta-analyses has exploded and, therefore, clinicians have become more familiar with this study design. The results of different trials are statistically combined to produce a more precise estimate [i.e. an estimate with a narrower confidence interval (CI)]. When a meta-analysis is performed after a credible systematic review, the results become m...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

دوره 18 7  شماره 

صفحات  -

تاریخ انتشار 2015